The Science Behind Precog

How we chose these six ingredients

The nootropic category runs on proprietary blends, sprinkled doses, and ingredient lists written to look impressive on a label. We built Precog the other way: every ingredient disclosed, every dose printed, nothing hidden behind a blend.

What researchers say about these compounds

We formulated Precog to only use clean ingredients that have been extensively studied and proven to improve mind and body.

These videos are embedded from their original publishers on YouTube and are not our content. No one appearing in them is affiliated with, compensated by, or endorsing Precog, and none has reviewed our formula. They are discussing the ingredients, not our product.

FORMULA BASED ON RESEARCH PUBLISHED IN
Sports Medicine
Frontiers Nutrition
The Journal of Nutrition
Journal of Psychiatric Research
Nutrients
BMC Complementary Medicine and Therapies

Journals listed are where the cited research was published.
They have no affiliation with Precog and do not endorse this product.

The ingredients

Creatine Monohydrate — 5,000 mg

Why it's in the formula. Creatine is the most-researched performance supplement in existence, with hundreds of human trials behind it. It works by replenishing ATP — the molecule your cells spend for energy. Muscle uses it. So does the brain, which consumes roughly 20% of your body's energy at rest.

What's established. For physical performance — strength, power output, and recovery — the evidence is about as strong as sports nutrition gets, and 5,000 mg daily is the standard maintenance dose used across that literature.

What the cognitive research actually shows. A 2024 systematic review and meta-analysis in Frontiers in Nutrition pooled 16 randomized controlled trials covering 492 adults. It found statistically significant benefits for memory, attention time, and information processing speed.

The certainty ratings matter as much as the findings. Using the GRADE framework, the authors rated the evidence for memory as moderate certainty. 

Read the meta-analysis →Read the 2023 review →

L-Theanine — 200 mg

Why it's in the formula. L-theanine is an amino acid from tea leaves associated in EEG research with increased alpha-wave activity — relaxed alertness rather than sedation. It's the ingredient responsible for Precog feeling smooth rather than edgy.

What the research shows. A 2019 randomized, placebo-controlled trial in Nutrients gave 200 mg of L-theanine daily to healthy adults for four weeks and found improvements in verbal fluency and executive function on cognitive testing, alongside reductions in stress-related measures.

Read the trial →

Citicoline — 300 mg

Why it's in the formula. Citicoline (CDP-choline) is a precursor to both acetylcholine — the neurotransmitter most associated with attention and memory — and phosphatidylcholine, a structural component of neuronal membranes.

What the research shows. A 2021 randomized, double-blind, placebo-controlled trial in the Journal of Nutrition gave 100 adults aged 50–85 with age-associated memory impairment either 500 mg of citicoline daily or placebo for 12 weeks. The citicoline group showed significantly greater improvement in episodic memory (p = 0.0025), with no serious adverse events in either group.

Read the trial →

Rhodiola Rosea — 200 mg (3% rosavins / 1% salidroside)

Why it's in the formula. Rhodiola is an adaptogen studied primarily for mental fatigue under demanding conditions — night shifts, exam periods, sustained cognitive load. The 3% rosavins / 1% salidroside standardization is the specification used in most of the clinical research, and 200 mg falls within the range those trials used.

Please read this part. Rhodiola is activating for some people and can cause jitteriness or interfere with sleep if taken late in the day. We recommend taking Precog in the morning or early afternoon. Rhodiola also has serotonergic activity and inhibits several drug-metabolizing enzymes. See the safety section below.

Read the review →

Lion's Mane Extract — 500 mg (fruiting body, ≥30% beta-glucan)

Why it's in the formula. Lion's mane (Hericium erinaceus) contains hericenones and erinacines, compounds studied for their effect on nerve growth factor. We use fruiting body extract standardized to at least 30% beta-glucans — not mycelium grown on grain, which is cheaper and dilutes the active fraction with substrate starch.

What the research shows. A 2023 randomized, double-blind, placebo-controlled pilot study in Nutrients gave 41 healthy adults aged 18–45 either 1.8 g of Hericium erinaceus or placebo. Participants performed faster on the Stroop task 60 minutes after a single dose (p = 0.005), and a trend toward reduced subjective stress appeared after 28 days (p = 0.051).

On nerve growth factor. The NGF mechanism is real but it is largely established in cell and animal studies.

Read the study →

N-Acetyl-L-Tyrosine — 300 mg

Tyrosine is the precursor to dopamine and norepinephrine. The research question it addresses is specific and interesting: under acute stress — cold, noise, sleep deprivation, sustained cognitive demand — catecholamine stores deplete, and supplemental tyrosine appears to help maintain working memory and cognitive flexibility under exactly those conditions. A 2015 review in the Journal of Psychiatric Research covers that literature.

Tyrosine is well tolerated, it supports the same catecholamine pathways the rest of the formula works alongside, and 300 mg contributes to daily intake. 

Read the review →

Safety and who this isn't for

Precog is formulated for healthy adults 18 and over.

Talk to your doctor before taking Precog if you:

  • Are pregnant, trying to conceive, or nursing
  • Have a kidney condition, or have been advised to limit creatine
  • Take prescription medication — rhodiola in particular inhibits enzymes involved in metabolizing a number of common drugs
  • Take an SSRI, MAOI, or other serotonergic medication — rhodiola has serotonergic activity
  • Have a history of bipolar disorder — activating adaptogens are generally cautioned against

Two things worth expecting:

Water weight. Creatine draws water into muscle cells. A gain of 2–4 lbs in the first weeks is normal and is not fat. If you're taking Precog for cognitive reasons and weren't expecting this, that's what it is.

Bloodwork. Creatine raises serum creatinine, which is the marker used to estimate kidney function. Supplemented people are routinely flagged on routine panels despite having entirely normal kidney function. Tell your doctor you take creatine before any blood work.

What we don't claim

  • Precog is not a treatment for any condition and is not a substitute for medical care, sleep, or a functioning routine.
  • The strongest creatine findings for cognition are in memory, at moderate certainty. Effects on overall cognitive function and executive function were not statistically significant in the meta-analysis we cite. We think the direction is promising. We don't think it's settled.
  • Results vary. Sleep, training, caffeine, stress, and a dozen other inputs affect cognitive performance more than any supplement does.

Full citation list

IngredientCitationLink
CreatineXu, Bi, Zhang, Luo. Frontiers in Nutrition, 2024PMC11275561
CreatineCandow, Forbes, Ostojic et al. Sports Medicine, 2023PMC10721691
L-TheanineHidese et al. Nutrients, 2019PMC6836118
CiticolineNakazaki et al. Journal of Nutrition, 2021PMC8349115
RhodiolaIshaque, Shamseer, Bukutu, Vohra. BMC Complementary and Alternative Medicine, 2012PMC3541197
Lion's ManeDocherty et al. Nutrients, 2023PMC10675414
TyrosineJongkees et al. Journal of Psychiatric Research, 2015ScienceDirect

Disclaimers

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The studies cited on this page examined individual ingredients, not Precog. Their authors have no affiliation with Precog, have not reviewed this product, and have not been compensated by us. Journals listed are where the cited research was published; they have no affiliation with Precog and do not endorse this product.

This page is for informational purposes and is not medical advice. Talk to your doctor before starting any supplement, particularly if you are pregnant or nursing, taking prescription medication, or have a medical condition.